Twenty matches were played across Africa from Friday and the Black Stars win over Lesotho in Group D stands out.
A brace each from Jordan Ayew, Dominic Adiyiah and goals from Sulley Muntari, Christian Atsu and Jerry Akaminko helped Ghana to the emphatic victory in Kumasi on Friday.
Africa Cup of Nations co-hosts Equatorial Guinea took a surprise lead in Tunisia on Saturday before going down 3-1 to a side bidding to reach its fifth World Cup tournament.
While the Black Stars strolled to the comfortable win other continental giants struggled with Nigeria needing a late goal to beat Namibia 1-0 at home.
New African champions Zambia suffered defeat in their first competitive match since winning this year’s Nations Cup.
The Chipolopolo suffered in the heat of Khartoum where Sudan won 2-0. Muhanad Tahir opened the scoring and Seifeddin Ali doubled their advantage to give Sudan a shock result.
South Africa left it late to save themselves from a shock defeat by Ethiopia on Sunday as qualifying continued for the 2014 World Cup.
With only 13 minutes of the game remaining, Katlego Mphela scored an equaliser to give Bafana Bafana a point.
On Saturday, Central African Republic recorded their first win in World Cup qualifying when beating Botswana 2-0 in Bangui.
Just five days after taking charge, new Ivory Coast Sabri Lamouchi led his new side to a 2-0 win over Tanzania in Abidjan.
Bidding for a third World Cup in a row, the Ivorians are two points clear in the group – after The Gambia and Morocco played out a 1-1 draw in Banjul.
Despite home advantage, Burkina Faso could only draw 0-0 with Congo in Ouagadougou.
Niger and Gabon fared no better on Sunday in Niamey, also drawing 0-0 .
Full results of the weekend’s World Cup qualifiers
Togo 1:1 Libya
Niger 0:0 Gabon
Angola 1:1 Uganda
Nigeria 1:0 Namibia
Benin 1:0 Mali
South Africa 1:1 Ethiopia
Zimbabwe 0:1 Guinea
Algeria 4:0 Rwanda
Burkina Faso 0:0 Congo
Senegal 3:1 Liberia
Sudan 2:0 Zambia
Tunisia 3:1 Equatorial Guinea
Côte d’Ivoire 2:0 Tanzania
Sierra Leone 2:1 Cape Verde Islands
Gambia 1:1 Morocco
Kenya 0:0 Malawi
Cameroon 1:0 Congo DR
Central African Republic 2:0 Botswana
Egypt 2:0 Mozambique
Ghana 7:0 Lesotho